After the synthesis of aspirin, the product was recrystallized for purification to rid the product of impurities. Experiments include i synthesis, purification, and characterization of aspirin by mp and tlc, ii percentage composition of a commercial aspirin tablet by titration, iii kinetics of the hydrolysis of aspirin to salicylic acid under various conditions, iv synthesis and characterization of. Acetylsalicylic acid, also known as aspirin, is one of the most widely used medications to reduce fever and is also used as a pain killer. Aspirin is one of the milder and least expensive pain relievers available. For use with application performs the synthesis of acetylsalicylic acid purification by recrystallization and using melting point to confirm identity, the mass of the recrystallized product is used to determine the yield of the synthesis. Synthesizing aspirin and oil of wintergreen purpose in this experiment, you will synthesize acetylsalicylic acid, commonly known as aspirin, and methyl salicylate, oil of wintergreen, from salicylic acid. In the synthesis of aspirin the oh group is the phenolic oh group attached to ring of the salicylic acid. Experiment 11 synthesis and analysis of aspirin introduction aspirin is most widely sold overthecounter drug. A series of experiments based on aspirin have been used in our high school chemistry laboratory. Synthesis and recrystallization of aspirin lab report uk essays.
Aspirin acetylsalicylic acid is a painrelieving compound. Synthesis and recrystallization of aspirin lab report. Quantitative analysis of aspirin further analysis conclusion the overall objectives of. Aspirin is a drug which is widely used today to deal with the symptoms of many minor illnesses ranging from general relief from aches and pain. Let this material sit at room temperature until the next lab period when you will determine your aspirin recovery. Give the balanced equation for the synthesis of aspirin, drawing the structures by hand. In this lab, you will determine the percent purity of two commercially available aspiring tablets using an acidbase titration.
Based on the mass of salicylic acid 2 g determine the maximum yield of aspirin theoretical yield from this amount of starting material. Aspirin is an effective analgesic pain reliever, antipyretic fever reducer and antiinflammatory agent and is one of the most widely used nonprescription drugs. You have been asked to evaluate a simple organic synthesis for aspirin and to determine if the synthesis merits further funding by santa monica pharmaceuticals. Take a small amount of the aspirin tablet and dissolve as much as you can in 3 drops of ethyl acetate. Synthesis and analysis of acetyl salicylic acid amy chan chem 290 section 1 november 25, 2002.
In this twoweek experiment the important area of organic chemistry will be illustrated by the preparation and characterization of two compounds. Casey goettel march 19, 2015 organic chemistry ii section 21 introduction purpose the purpose of this experiment is to synthesize and analyze aspirin by the esterification of salicylic acid to aspirin using acetic anhydride. Recall that last week you did the reaction shown to prepare aspirin. All minor components described in the how to write a strong lab report general guidelines note that the only chemical characterization test results you need report on are for the ferric chloride test. Synthesis of aspirin lab report 2989 words bartleby. The purity is compared to the commercial asa and checked via melting point determination and colourimetry. Synopsis the objective of this experiment is to enable us to conduct the synthesis of aspirin, reinforce the skills of recrystallisation an. It is a derivative of salicylic acid which is also an. Write detailed mechanisms showing how pyridine and phosphoric acid catalyze the formation of acetylsalicylic acid.
Compound molecular weight hazards density melting point salicylic acid 8. Aspirin is the most widely used overthecounter drug in the world. The purpose of this experiment was to find out how a reaction undergoes for a globally known painkiller called aspirin, and to become familiar with achieving successful yields. To determine which of four catalysts yields the fastest reaction rate in the acetylation of salicylic acid 1 to form acetylsalicylic acid 2. The mechanism for this synthesis provides examples of three major classes of chemical reactions. The purpose of this lab is to investigate the purity of the acetylsalicylic acid asa, aspirintm that was syntesized in the lab using the techniques of crystallization and filtration. Aspirin is used medically to reduce fever and pain. Synthesis of acetylsalicylic acid aspirin using acid. Synthesis of aspirin and oil of wintergreen revision f8 page 3 of 7 procedure synthesis of aspirin 1. Aug 08, 2016 synthesis of aspirin lab report essay example for free newyorkessays database with more than 65000 college essays for studying. It has the ability to reduce fever an antipyretic, to reduce pain an analgesic, and to reduce swelling, soreness, and redness an antiinflammatory agent. Jan 30, 20 synthesis of aspirin acetylsalicylic acid using acid and base catalysis. The objective of this experiment is to enable us to conduct the synthesis of aspirin, reinforce the skills of recrystallisation and reinforce the technique of melting point determination. This figure mainly reflects purchase of 16,000 tons of aspirin tablets or 80 million tablets a year.
The average tablet contains about 325 milligrams of the active ingredient acetylsalicylic acid combined with an inert binding material such as starch. E29 preparation of aspirin acetylsalicylic acid and thin. Unsubscribe from north carolina school of science and mathematics. Do not lose this container or its contents, you will use them later. This is a lab report on the synthesis of organic aspirin. This week you will use nmr, ir, and melting point to characterize your product. Aspirin is produced from an acid catcalled reaction between salicylic acid with acetic anhydride. Lab report the report for this experiment is an abbreviated lab report and need only include. The laboratory synthesis of a compound usually requires the product to go through a series of steps to isolate it from the reaction mixture and any soluble impurities. At the lab bench, the aspirin crystallized out of the solution. The synthesis of aspirin procedure steps 3 5 were repeated twice more for two more titrations. The purpose of this lab is to synthesize and characterize high purity aspirin. After the reaction heating period is over, the excess unreacted. Report the theoretical yield and the percent yield of the aspirin product.
Many of the liquids used in this experiment are quite volatile. The synthesis of aspirin chemistry standard level lab report data collection and processing and conclusion and evaluation date. The experiment described here differs from these typical syn. To download a student copy of the lab handout, click the link to the file at the bottom of this page. Preparation of aspirin experiment 5 lab report name first lastmcgill id number demonstrator section lab date complete table 2, showing all calculations.
Add 5 ml of 1 m sodium hydroxide and carefully heat the mixture until all solid dissolves. Table 2 results parameter value calculations salicylic acid mol acetic anhydride mol theoretical yield of aspirin g weight of aspirin. The synthesis of a medicinal agent aspirin by walter scharf and charles malerich natural scienceschemistry baruch college new york, ny 10010 introduction salicylicacidcontaining compounds derived from willow bark have been in use for hundreds of years as antipyretic feverreducing, analgesic pain killing, and antiinflammatory agents. Aspirin iii data analysis and report guide duration. This aim of this experiment focuses on the synthesis of pure aspirin acetylsalicylic acid from ethanoic anhydride and salicylic acid while using concentrated sulfuric acid as a catalyst for the. The crude product and the purified product can be tested using ferric chloride. Preparation of aspirin experiment 5 introduction in this experiment you will prepare a sample of aspirin, recrystallize the raw product, and determine the percentage yield of the aspirin based on the limiting reactant. H 2 so 4 use a dropper, h 2 so 4 is highly corrosive and swirl the flask gently until the salicylic acid dissolves heat the flask gently on the steam bath for at least 10 minutes.
Salicylic acid, whose name comes from salix, the willow family of plants, was derived from willow bark extracts. Synthesis of aspirin lab chem 165 linkedin slideshare. The preparation of aspirin is an example of an organic synthesis called esterification. Transfer this sample into a 125 ml erlenmeyer flask. Aspirin synthesis lab report by eddie zhang on prezi. Aspirin is a drug that is usually used to relieve minor aches and pain and other medical uses such as antiinflammatory medication. The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap. Classroom resources aspirin synthesis and spectroscopy. Experiment 22 synthesis of aspirin and oil of wintergreen goals. Aspirin works by suppressing the synthesis of prostaglandins and thromboxanes in the human body3,4,5. In addition, it can prevent blood clotting, meaning in small amounts it can be helpful in preventing heart attacks or stroke. The aspirin synthesized in this experiment will be crystallized from solution. Synthesis of aspirin pre lab assignment study the sections related to stoichiometry and limiting reactant in your textbook. In this experiment, the salicylic acid is the limiting reactant and the acetic anhydride is in excess.
Pdf this aim of this experiment focuses on the synthesis of pure aspirin. Sp11 1021 synthesis of aspirin and oil of wintergreen. Prostaglandins function as local hormones produced in the body that aid in the transmission of pain signals, regulate the hypothalamic thermostat, and inflammation2. Aspirin is the common name for the compound acetylsalicylic acid, widely used as a fever reducer and as a painkiller. Data, results, references, discussion and conclusions section. Aspirin synthesis tap water was heated on a steam bath in a 250 ml beaker. Organic synthesis of aspirin abstract the purpose of this experiment is to synthesize a common organic product called ecstatically acid aspirin, and to become familiar with the optimum conditions needed for successful yields. The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water. This is not an example of the work produced by our essay writing service. Report data collected and subsequent calculations to all equipment should be returned to.
This product will be impure because of unreacted salicylic acid and visible spectroscopy can help determine the percentage of the impurity of the product. In this lab, we synthesized aspirin using both acid catalysis and base catalysis. An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples. Synthesis and spectral analysis of aspirin synthesis and. Experiment 22 synthesis of aspirin and oil of wintergreen. It is one of the oldest and widely used drugs in medicine.
Synthesis of aspirin lab report and analysis odinity. Experiments with aspirin journal of chemical education. Aspirin is an ester that has high molecular weight and it not soluble in water hence the solid can be separated by crystallization process. It is the twostep synthesis of aspirin starting from oil of wintergreen. If you need guidance, follow the steps in the report sheets. One of the simpler organic reactions that can be carried out is the formation of an. Aspirin synthesis your team of scientists has been hired by the drug research division of santa monica pharmaceuticals, a new startup company formed by some smc alumni.
Synthesis of aspirin in the first part of the experiment, aspirin was synthesized. Abstract aspirin, or acetylsalicylic acid, is a widely used drug. Organic synthesis of aspirin chemistry formal lab essay. It is carried out to form ester from an acid and an alcohol. The use of aspirin had its origin in the 18 th century, when it was found that an. Williamson, macroscale and microscale organic experiments, 2nd ed. Esterification is the acid catalyzed reaction of a carboxyl cooh group and an oh group of an alcohol or phenol to form a carboxylate ester. H 3 po 4 safety gloves and safety goggles are mandatory when anyone is performing an experiment in the lab. You will need to add up molar masses by counting the atoms shown in the structures. An ester is a compound that is formed when an acid reacts with an alcohol, oh group. Synthesis and characterization of aspirin chemistry m01b lab 07 100 advance study assignment.
May 11, 2015 rasan cherala synthesis of aspirin lab purpose. Preparation and standardization of hcl procedure part 4. Below are many of the experimental steps you will perform in this lab. The purpose of this lab was to synthesize aspirin, determine the theoretical yield, compare the percent yield to the theoretical yield and test the purity of aspirin by adding iron iii. The students will be able to better discuss and understand the concepts and warnings. This reaction is the reverse of the synthesis reaction. View notes aspirin synthesis lab report from chem 106 at case western reserve university. Synthesis of aspirin lab report introduction the purpose of this experiment was to synthesize a small.
The onestep synthesis of aspirin from salicylic acid is described in many general chemistry laboratory manuals 8 and may be traced to a report by brown and friedman 6. Chemistry 51 experiment 11 synthesis and analysis of aspirin. In this lab, you are going to synthesize a very popular and widely used medicinal drug, aspirin acetylsalicylic acid. Pdf preparing a pure aspirin acetylsalicylic acid researchgate. Ferric chloride forms highly colored complexes with. Aspirin synthesis lab report by alissa lockwood on prezi. Aspirin part 1 synthesis and recrystallization 2017 duration. Lab report synthesis and characterization of aspirin acetylsalicylic acid the synthesis and characterization of aspirin acetylsalicylic acid. Synthesis of aspirin experiment chemistry libretexts.
This laboratory introduces students to aspects of practical organic chemistry including synthesis, crystallization, stoichiometry, and percent yield. The purpose of this experiment was to make aspirin via esterification, and to determine the percent yield we as a lab group made. It is a mild analgesic, useful in the alleviation of bodily pains and aches, and it also possesses antiinflammatory properties useful in reducing fever. It is safe to discard of the filtrate down the sink with water. The day 1 aspirin analysis powerpoint presentation available for download is an introduction to the lab experiment based on students having the lab andor lab background to read prior to coming to the laboratory. Aspirin is synthesized through the reaction of salicylic acid with acetyl anhydride. A major impurity that could be found in the crude product would be unreacted salicylic acid. Crystallization will be induced by scratching the glass beaker to create nuclei around which aspirin may crystallize.
The usefulness of functional groups will be illustrated as well as the use of nmr, ir, and melting point in characterizing a product. Study 10 aspirin synthesis lab quiz flashcards from brittni t. After synthesis and analysis, it will be determined if the crude and recrystallized samples were composed solely of either salicylic acid, acetylsalicylic acid, or a combination of both 3. Nov 18, 20 after the synthesis of aspirin, the product was recrystallized for purification to rid the product of impurities. I understand the safety information demonstrators initials lab work 20 safety note.
In the presence of moisture, aspirin may decompose hydrolysis into salicylic acid and acetic acid. Organic synthesis of aspirin chemistry formal lab essay sample. Mar 19, 2015 synthesis and spectral analysis of aspirin by. In folk medicine, willow bark teas were used as headache remedies. You will be able to see how two very different organic compounds can be made from the same common starting material.
Be sure to consult the procedure for the detailed instructions. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Organic synthesis of aspirin abstract the purpose of this experiment is to synthesize a common organic product called acetylsalicylic acid aspirin, and to become familiar with the optimum conditions needed for successful yields. The purpose of this experiment is to synthesize a common organic product called acetylsalicylic acid aspirin, and to become familiar with the optimum conditions needed for successful yields. Synthesis of aspirin inquiry based drug analysis for. This is the second of two weeks related to aspirin. The purpose of this experiment is to create aspirin by reacting salicylic acid with acetic anhydride. Aspirin synthesis lab quiz honors chemistry 2 with sparks. Determine the theoretical yield of aspirin that can be obtained from the addition of 2.
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